Polynucleotides: The new miracle cure or a risky trend?
Abby, 29, receives an innovative polynucleotide treatment to improve her skin in Manchester. Experts warn of risks.

Polynucleotides: The new miracle cure or a risky trend?
In recent years, aesthetic medicine has developed rapidly and more and more people are turning to innovative procedures for skin rejuvenation. A trend that is currently causing a stir in Manchester is polynucleotide treatments. These molecules, derived from trout or salmon sperm, promise to improve skin by stimulating collagen and elastin production. Abby, 29, is one of the brave ones who has taken this step and is undergoing treatment at a beauty clinic to combat skin problems such as acne and scars. According to BBC Thai, many celebrities, including Charli
Treatment costs range from £200 to £500 per session, with multiple applications recommended over a short period of time. But reports of results are mixed: some customers report visible improvements, while others notice no significant changes. Dr. John Pagliaro, a dermatologist, raises concerns about the safety and effectiveness of these procedures, especially since there is a lack of comprehensive studies. In fact, experts are scrambling to investigate potential risks and unreliabilities in the use of polynucleotides as the number of suppliers grows.
Mode of action and areas of application
Polynucleotides are not only a new topic in aesthetic medicine, they also show promising results in various applications. These complex molecules, which have recently gained importance, promote cell proliferation and improve skin elasticity. According to research summarized in a literature review, polynucleotides achieve significant success in improving skin conditions such as wrinkles, scars, dark circles under the eyes and melasma. It is important to note that results can vary, which is partly due to insufficient research - a problem that experts also address.
Another advantage of polynucleotides is their compatibility. They support the body's own repair mechanisms and improve the appearance of the skin without having to resort to invasive methods. The application usually involves a thorough consultation followed by the injection, which takes about 30 to 45 minutes. 3 to 4 sessions spaced 3 to 4 weeks apart are recommended. The first visible results can usually be seen after the second session.
Safety and regulations
Although polynucleotides are registered as a medical device in the UK, they are not subject to the strict controls that apply to medicines. In the USA, the FDA has not yet approved it, which is causing concern among many experts. In Thailand the product is sold under the name “Rejuran”. There are some properly registered products here, but also without the legal framework for medication. Experts warn - whose opinion is also supported by the analysis from NCBI - about potentially inadequately tested products on the market and urgently call for clearer regulations.
Charlotte Bickley, a 31-year-old patient, reported negative experiences, including skin infections and the appearance of increased dark circles under the eyes after her treatment. Healthy skepticism is therefore advisable before deciding on such interventions. The industry is growing, and with it the responsibility to inform users of the possible risks and to provide transparent information.
In summary, polynucleotides represent an exciting but controversial advance in aesthetic medicine. While they have the potential to gently promote skin health, those interested are advised to do their research and think carefully before taking the plunge. If you are looking for a way to improve your own skin, you should not be afraid to weigh up various options and seek advice from experts. The results can be convincing, but as in all areas of healthcare, it is important to act with caution - after all, it is your own skin.